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Research

Outcome Study ONTARGET

1 Apr 2008

ONTARGET results have been released- click here.

A large, simple, randomized, double-blind, ... › More

Glycemic Load, Weight Loss and Cardiovascular Disease Risk

11 Aug 2007
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors. The study compares a conventional reduced-fat, ... › More

Study to Assess If Internet-Based Tailored Advice Could Modify Behaviour to Improve Health

2 Jul 2007
The purpose of this trial is to find out if a special website might help people discover if they have high cholesterol and then enable them to manage their cholesterol more appropriately. The primary ... › More

Telmisartan vs. Losartan for Improvement of Renal Function in Hypertensive Diabetic Patients With Overt Nephropathy.

1 Jul 2007
A number of blood pressure lowering drugs in the class known as angiotensin receptor blockers (ARB) have been shown to slow the decline in kidney function of patients with type 2 diabetes, high blood ... › More

SMOOTH - Blood Pressure Control in Diabetic/Obese Patients

20 Jun 2007
The primary objective of the SMOOTH study was to demonstrate that, when combined with hydrochlorothiazide (12.5 mg), telmisartan (80 mg) is at least as effective and possibly superior to valsartan ... › More

A Study To Evaluate the Effect of Rosuvastatin On Intravascular Ultrasound-Derived Coronary Atheroma Burden (ASTEROID)

9 Jun 2007
The purpose of this study is to see if 40 mg of rosuvastatin taken daily will reduce the atherosclerosis (fatty deposits) in your arteries › More

Lipitor In The Prevention Of Stroke, For Patients Who Have Had A Previous Stroke (SPARCL)

18 May 2007
To determine whether Lipitor reduces stroke, compared to placebo in patients who have had a previous stroke or transient ischemic attack. › More

A Trial of INO-1001 in Patients Undergoing Heart Surgery That Involves Heart-Lung Bypass

9 Apr 2007
The purpose of this study is to assess the safety of INO-1001, an intravenous PARP (poly-[ADP ribose] polymerase) inhibitor, in patients undergoing heart surgery. The study also measures whether ... › More

ThromboEmbolism Prevention Efficacy and Safety Trial (TEMPEST)

26 Mar 2007
The purpose of this study is to gain additional safety information as well as to determine after the study drug has been given to patients who have undergone total hip replacement surgery, whether ... › More

Effect of Abdominal Obesity on Lipoprotein Metabolism

17 Mar 2007
Abdominal obesity is strongly associated with dyslipidemia, which may account for the associated increased risk of atherosclerosis and coronary disease. Hypothesis: Reduction in abdominal fat mass by ... › More

Trials

FIELD -Fenofibrate Intervention and Event Lowering in Diabetes

12 Nov 2007
The FIELD trial "Fenofibrate Intervention and Event Lowering in Diabetes" aims to determine whether treatment with fenofibrate, a potent modifier of blood lipid levels, will reduce the risk of fatal ... › More

Ezetimibe/Simvastatin in Patients With Metabolic Syndrome

5 Nov 2007
A 6-week clinical trial in patients with metabolic syndrome and hypercholesterolemia at high risk for coronary heart disease to study the effects of ezetimibe/simvastatin and atorvastatin on lipids. › More

High Density Lipoprotein Turnover

11 Sep 2007
The objective of the study is to evaluate the effect of Rimonabant 20mg in comparison to placebo, on HDL and VLDL lipoprotein kinetics, over a 12 months period. › More

Efficacy & Safety of Dronedarone Versus Amiodarone for the Maintenance of Sinus Rhythm in Patients With Atrial Fibrillation (DIONYSOS)

10 Jul 2007
The objective of this study is to compare the efficacy and safety of dronedarone to that of amiodarone for the treatment of patients with atrial fibrillation. › More

FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)

1 Jul 2007
This study is an international, multi-center, randomized, double-blind, placebo-controlled study in subjects with PAH who are currently receiving approved therapy for their PAH (i.e. endothelin ... › More

Optimal Loading Dose of SR25990C in Patients Planned for Percutaneous Coronary Intervention

17 Jun 2007
The purpose of this study is to evaluate whether a higher dosage of clopidogrel with aspirin (two doses) will decrease the risk of ischemic complications (cardiac death, stroke, myocardial ... › More

Alternative Risk Markers in Coronary Artery Disease (ARMCAD)

6 Jun 2007
The aim of this study is to assess several known and a few novel risk-factors (heart rate variability, pulse wave analysis, high-sensitivity CRP and BNP) prior to planned elective coronary ... › More

Ancrod (Viprinex) for the Treatment of Acute, Ischemic Stroke

28 May 2007
The primary purpose of this study is to determine whether a brief intravenous infusion of ancrod started within 6 hours of stroke onset improves functional outcome at 3 months. › More

Panic Disorder and Cardiac Risk

5 May 2007
The reason for increased cardiac mortality in panic disorder has not been precisely identified, but possibly is due to chronic activation of the cardiac stimulant (sympathetic) nerves, which may ... › More

'CardioFit' for the Treatment of Heart Failure

23 Apr 2007
In this study, the safety and efficacy of a new vagus nerve stimulating system will be evaluated. This study will compare whether the new device improves Heart Failure parameters in Class II - III ... › More

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